Genoa Portofino Italy
Embarkation day. MSC Opera sails at 6:00 PM.

10-Night Western Mediterranean aboard MSC Opera · Departing September 30, 2026 from the Port of Genoa Portofino Italy.
MSC Opera leaves Genoa Portofino Italy on Wednesday, September 30, 2026 at 6:00 PM and returns Saturday, October 10 at 9:00 AM: 10 nights with 7 ports of call (Marseille, Malaga, Cadiz, Lisbon, Alicante, Mahon and Olbia) and 2 days at sea. It is the only upcoming departure of this itinerary on MSC Opera. September averages 81°F highs and 53°F lows across the ports on this route.
The itinerary safety score for this sailing is 7.4 out of 10, averaged across 8 ports. Inside cabins dropped $39 on Sep 29.
The graph below tracks historic price of the MSC Opera cruise ship departing September 30, 2026. The most recent price for this sailing starts at $1,532 ($154 per night) for an Inside Cabin. Compared to the average price of $1,501 ($151 per night), this represents a recent increase of 2%.
MSC Opera cruise departing September 30, 2026 — 10-night itinerary. Current Inside Cabin price: $1,532 ($154 per night). Average price: $1,501.
Prices change often and may differ at checkout. Click to see the latest available price.
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Day at sea aboard the Opera — explore the ship's signature dining, entertainment, and onboard activities.
Day at sea aboard the Opera.
Independent shore excursions in every port on this MSC Opera itinerary, booked directly with the operator who runs them. We flag the ones that guarantee you're back on board before the gangway lifts.
These are the eight most reviewed. Genoa Portofino Italy has plenty more — browse the full catalogue and book direct with the operator.
SEE ALL GENOA PORTOFINO ITALY EXCURSIONSPricing and availability are provided by the operator. Booking happens on their own site — MSC Opera sails September 30, 2026, and Gangwaze earns a commission at no extra cost to you.
Based on comprehensive research of cruise port safety information, including recent crime reports, travel advisories, Global Peace Index rankings, and specific port security concerns, we've created a "safety score" for each cruise port stop. The overall rating below represents a combined score for your specific cruise itinerary.
Scores combine recent crime reports, government travel advisories, Global Peace Index rankings, and port-specific security incidents. Refreshed monthly.
Genoa and Portofino are generally safe for cruise travelers, but vigilance against petty crime like pickpocketing is advised.
Travelers in Marseille should stay vigilant in certain neighborhoods due to higher crime rates and secure their belongings in crowded areas.
Travelers in Malaga should remain vigilant against petty theft and pickpocketing, especially in crowded areas and popular attractions.
Travelers should stay vigilant against petty theft in crowded areas while enjoying the safe and welcoming atmosphere of Cadiz.
Travelers in Lisbon should stay vigilant in crowded areas and on public transport to avoid petty theft and keep belongings secure.
Travelers in Alicante should stay vigilant against petty theft, especially in crowded areas, while securing their belongings.
Mahon is a safe cruise destination with low crime rates, though travelers should stay vigilant against pickpocketing in crowded areas.
Olbia is generally safe for travelers, but vigilance against petty theft and pickpocketing is advised in crowded areas.
The MSC Opera has a construction date of 2004 and a total size of 65,591 gross tons. The ship measures 902 feet in length. MSC Opera is included in MSC's Lirica class. At full capacity, the Opera holds 2,679 passengers. That includes 1,951 cruise vacationers and 728 staff members. The Opera total number of staterooms is 1,068.
Hop to the previous or next sailing on this ship, or browse the full schedule.