Genoa Portofino Italy
Embarkation day. MSC Opera sails at 6:00 PM.

16-Night Msc Grand Voyages aboard MSC Opera · Departing October 31, 2026 from the Port of Genoa Portofino Italy.
MSC Opera leaves Genoa Portofino Italy on Saturday, October 31, 2026 at 6:00 PM and ends in La Romana, Dominican Republic on Monday, November 16 at 7:00 AM: 16 nights with 6 ports of call (Marseille, Barcelona, Tangier, St. John's, Philipsburg and Basseterre) and 9 days at sea. It is the only upcoming departure of this itinerary on MSC Opera. October averages 84°F highs and 69°F lows across the ports on this route.
The itinerary safety score for this sailing is 6.6 out of 10, averaged across 8 ports.
The graph below tracks historic price of the MSC Opera cruise ship departing October 31, 2026. The most recent price for this sailing starts at $949 ($60 per night) for an Inside Cabin. Compared to the average price of $1,006 ($63 per night), this represents a recent decrease of 6%.
MSC Opera cruise departing October 31, 2026 — 16-night itinerary. Current Inside Cabin price: $949 ($60 per night). Average price: $1,006.
Prices change often and may differ at checkout. Click to see the latest available price.
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Day at sea aboard the Opera — explore the ship's signature dining, entertainment, and onboard activities.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Day at sea aboard the Opera.
Independent shore excursions in every port on this MSC Opera itinerary, booked directly with the operator who runs them. We flag the ones that guarantee you're back on board before the gangway lifts.
These are the eight most reviewed. Genoa Portofino Italy has plenty more — browse the full catalogue and book direct with the operator.
SEE ALL GENOA PORTOFINO ITALY EXCURSIONSPricing and availability are provided by the operator. Booking happens on their own site — MSC Opera sails October 31, 2026, and Gangwaze earns a commission at no extra cost to you.
Based on comprehensive research of cruise port safety information, including recent crime reports, travel advisories, Global Peace Index rankings, and specific port security concerns, we've created a "safety score" for each cruise port stop. The overall rating below represents a combined score for your specific cruise itinerary.
Scores combine recent crime reports, government travel advisories, Global Peace Index rankings, and port-specific security incidents. Refreshed monthly.
Genoa and Portofino are generally safe for cruise travelers, but vigilance against petty crime like pickpocketing is advised.
Travelers in Marseille should stay vigilant in certain neighborhoods due to higher crime rates and secure their belongings in crowded areas.
Travelers should stay vigilant against pickpocketing in crowded areas and secure their belongings to ensure safety while enjoying the city.
Travelers should remain vigilant in Tangier, especially in the medina, to avoid petty crime and harassment while exploring the city.
St. John's is generally safe for travelers, but vigilance is advised due to potential petty theft and risks in certain neighborhoods after dark.
Philipsburg is generally safe for cruise travelers, but remain vigilant against petty theft in crowded areas and secure personal belongings.
Basseterre is generally safe for cruise travelers, but it's wise to stay vigilant against petty theft and avoid poorly lit areas at night.
In La Romana, stay vigilant and take precautions in less populated areas to minimize crime risks while enjoying the attractions.
The MSC Opera has a construction date of 2004 and a total size of 65,591 gross tons. The ship measures 902 feet in length. MSC Opera is included in MSC's Lirica class. At full capacity, the Opera holds 2,679 passengers. That includes 1,951 cruise vacationers and 728 staff members. The Opera total number of staterooms is 1,068.
Hop to the previous or next sailing on this ship, or browse the full schedule.